Multi Media Disso Kit을 소개합니다. 본문
What is Multimedia Dissolution?
Multimedia dissolution is to mimic the invivo condition by doing invitro test and pH/buffer selection.
Media such as FaSSGF, FaSSIF and FeSSIF can also be used in multimedia dissolution to better the mimic in vivo conditions and to develop discriminatory dissolution methods.
When is Multimedia dissolution used:
If the dissolution is slower than gastric emptying, (for BCS Class II and / or IV drug) a dissolution profile with multiple time points in multimedia is recommended.
The MMD Kit consists of the following components:
1. MMD driver
2. MMD replenishment vessel kit
An existing Electrolab dissolution tester can be easily converted into a MMD tester with the MMD kit.
Benefits:
- Perform small batches of different media
- Only firmware upgrade is required
- Variable starting media volumes possible
- Variable stirring speeds at each time point
- Variable dilution factors for different time points
- Different reports obtained for different media used
- Automatic sampling possible
Configurations:
The multimedia dissolution drivers are available for the following Electrolab models
1. TrustETM – Basic, manual and offline modes- 8 and 14 station, 150 mL, 250 mL , enhancer cell and 2 L dissolution
2. VeritasTM – Basic, online with HPLC and offline modes- 8 and 14 station
MULTYMEDIA DISSOLUTION KIT : MMD
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